In this work, researchers describe the presence of viral antigens from porcine respiratory and reproductive virus contain antigenic viral protein in exosomes derived from animals that have overcome the disease. This research, which has been carried out in the past year in collaboration with the University of Lleida, reinforces the possibility of designing new vaccines for the prevention of this devastating disease in animal health.

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Free webinar | Novel use of EVs in the search for biomarkers

Join Dr Juan Manuel Falcón Wednesday, June 15 (2pm GMT/ 9am EST), as he reviews our current knowledge of extracellular vesicles (EVs) within a diagnostic environment, discusses the transfer of EV enrichment applications into clinical environments, and answers your questions during a live Q&A session.

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Cell-cell signaling communication is a key event during development and has to occur in a precise manner; its misregulation is one of the most prevalent causes of diseases such as cancer, congenital malformations and neurological disorders. The group demonstrates a direct-delivery of one of the above key signaling molecules, Hedgehog, through specialized filopodia (also called cytonemes). This mechanism facilitates concentration and spatial restriction of a signal in a short and long distance communication (Bischoff et al., Nat. Cell. Biol. 2013). More recently the group demonstrate that exosomes are the Hedgehog carriers in cytoneme-mediated transport and secretion. (Gradilla et al., Nat. Comm. 2014).

Exosomes are nanoscaled vesicles of endocytic origin that feature well-defined structure and composition. The implication of exosomes in several intercellular communication mechanisms suggests that, in addition to their potential as biomarkers and novel therapeutical agents, these vesicles could hold precious insights into the mechanisms behind altered functionality and pathological processes. Aware of their potential in the future of personalized medicine, the Fundación Ramón Areces has funded three projects on research on exosomes. Remarkably, the principal investigators are all members of REdiEX

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