Ikerbasque Research Professor. Lab.3- Exosomes group. Metabolomics Unit & Platform. CIC bioGUNE, CIBERehd Derio, 48160, Bizkaia SPAIN
Biosketch & Research interests
Ikerbasque Research Professor at CIC bioGUNE (Derio, Bizkaia, Spain) leading the EXOSOMES group of the metabolomics unit and the METABOLOMICS platform of the center. Dr.Falcón is a biologist with strong biochemical and cellular biology backgrounds and wide experience in performing high-content omics-based analyses. During his Ph.D at the Biomedical Research Institute "Alberto Sols" in Madrid, Dr. Falcón carried out an extensive biochemical analysis of the Ycf1 carrier of S. cerevisiae, as model for the study of CFTR protein that is responsible of Cystic Fibrosis (CF) human disease. As postdoctoral fellow in the Universidad Autónoma de Madrid participated in the generation of the knockout mouse for the POMT1 gene codifying the O-mannosyltransferase protein 1, an essential enzyme in development, and with implications in muscular dystrophies. As postdoctoral researcher in the Human Genetics Department of University of California, Los Angeles (UCLA, USA) he focused on the biochemical and functional characterization of proteins associated with the Hermansky-Pudlak syndrome (HPS) which is caused by defects in the formation of specialized organelles named lysosome-related organelles (e.g. melanosomes, platelet dense granules) using mouse and flies as model organisms. In 2006, he moved to CIC bioGUNE and started the study on EXOSOMES –extracellular vesicles of endocytic origin- as a source for biomarker discovery and a tool for therapeutic applications, and METABOLOMICS as a platform for unraveling markers and metabolic pathways altered in diseases. Thanks to a number of national and international collaborations Dr. Falcon´s group has characterized exosomes secreted by many in vivo and in vitro experimental models of several diseases, as well as from different body fluids and applied “omics” technologies in their study. In addition, identification of MOLECULAR CHAPERONES that increase in vivo stability of proteins implicated in METABOLIC RARE DISEASES-caused by protein miss-folding (e.g. Cystic fibrosis, Porphyries) is a collaborative project in which Dr. Falcon´s group is actively achieving. Currently, he founder member of Spanish association for innovation and investigation on exosomes (GEIVEX) and member of the management committee of the European Network to study Microvesicles and Exosomes in Health and Disease (Me-Had).